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Curriculum Vitae
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| Name |
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Franziska Schädeli Stark |
| Date of birth |
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February 6, 1967 |
| Place of birth |
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Berne (Switzerland) |
| Citizenship |
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Switzerland |
| Places of origin |
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Kirchlindach, BE, and Zwingen, BL |
| Marital status |
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married |
| Spouse's Name |
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Robert Stark |
| Mother tongue |
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German |
| Children |
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Sebastian Timothy (October 17, 2000); Georg
Emanuel (June 22, 2002); Klara Lynne (Ocotber 20, 2005) |
| Address (home) |
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Baumgartenweg 6, 3063 Ittigen, Switzerland |
| Phone, email: |
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++41 31 991 47 28, franziska@stark-schaedeli.ch |
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| 1974−1978 |
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Primarschule Uettligen (BE) |
| 1978−1983 |
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Sekundarschule Uettligen (BE) |
| 1983−1987 |
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Städtisches Literargymnasium
Bern-Neufeld |
| 09/18/1987 |
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Maturity examination |
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| 1988−1993 |
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Studies of Pharmacy at the Medical Faculty of
the University of
Berne, Switzerland |
| 1990−1991 |
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Practical training as a Pharmacist,
Rathaus-Apotheke Bern, supervised by Dr.pharm. St.
Fritz |
| 1994−1997 |
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Division of Nephrology, Department of Medicine,
University of Berne
Curriculum to achieve a PhD degree in pharmacology,
supervised by Dominik E. Uehlinger, MD, and Felix
J. Frey, MD.
- Subject: Population pharmacokinetic/-dynamic
(PKPD) methods in patients on hemodialysis and in
renal transplant recipients. The computer program
NONMEM was used for PKPD data analyses.
- Project 1: Population PK study to assess
dosing guidelines for intravenous vancomycin in
high-flux hemodialysis: Design, planning and
organization of a clinical trial in 26 patients
on chronical hemodialysis; development of a HPLC
assay to quantify vancomycin serum
concentrations; population PK data analysis.
- Project 2: Clinical trial to compare the
pharmacokinetics of two galenic formulas of
cyclosporine A (Sandimmune, Sandimmune Neoral) in
renal transplant recipients: Design, planning and
organization of a clinical trial in renal
transplant recipients with population (n=50) and
classic study (n=10) design; comparison of
population PK modeling with classic
non-compartmental data analysis.
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| 08/25/1997 |
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PhD graduate examination in pharmacology and
clinical pharmacology |
| 09/29/1997 |
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Defense of the thesis: "Population
pharmacokinetic methods in patients on renal
replacement therapy: Urea kinetics and dialysis
treatment time predict vancomycin elimination during
high-flux hemodialysis" |
| 02/1998−01/1999 |
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Swiss National Science Foundation fellowship for
prospective researchers at the University of
California, San Francisco, (UCSF), USA.
- Project title: Parametric and semi-parametric
models in population pharmacokinetic and
pharmacodynamic data analysis using HIV
antiretroviral therapy as a model situation
- Supervisors: Davide Verotta, PhD, and Lewis
B. Sheiner, MD
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| 02/1999−01/2000 |
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Extension of the fellowship by UCSF
- Project 1: Semi-parametric model to describe
long-term HIV plasma levels in highly active
antiretroviral therapy (HAART): Development of
models to describe the non-linearities of viral
load observed during HAART. Main objective: to
find simple non-linear empirical population
models that can predict both long term
suppression and rebound of viral load during
HAART. Example data of AIDS Clinical Trial Group
Protocol 315 were available.
- Project 2: Influence of arterial vs venous
plasma sampling for pharmacodynamic model
selection and parameter estimation at the example
of nicotine: In a PK/PD link model arterial
concentrations were represented either by
observed arterial data or were estimated from
observed venous data using deconvolution.
Different PD models of acute tolerance as well as
non-tolerance were compared.
- Project 3: Physiological model of HIV
dynamics including immune response in order to
better understand HIV dynamics and eventually
antiretroviral drug effects. Scientific knowledge
of several disciplines (immunology, virology,
pharmacology) was combined to devise a
mathematical model of HIV dynamics to simulate
realistic time courses of HIV, infected and
non-infected CD4+ Lymphocytes, and CD8+
Lymphocytes, given prior knowledge on the
involved parameter distribution. Objectives: 1.
Simulation study. 2. Aid in design of future
clinical trials.
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| 10/20/1993 |
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Swiss Federal Diploma of Pharmacy |
| 12/08/1997 |
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PhD in Pharmacology, Faculty of Medicine,
University of Berne, Switzerland |
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| 2000 |
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Scientific Assistent, Division of Nephrology,
University of Bern.
- Main Project: Urea kinetics modeling in
hemodialysis patients. Improvement of dialysis
treatment guidelines by an improved algorithm to
predict post-dialysis serum urea concentration
rebounds.
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| 2001-2002 |
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Scientific information service for pharmacists,
Swiss pharmacists association, Bern |
| 2003- |
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Clinical pharmacologist in the Modeling &
Simulation Group at Hoffmann-La Roche in Basel. Pharmacokinetic and -dynamic modeling and simluation in drug development (focused on oncology) |
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| 01/1997 |
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Technik des wissenschaftlichen Vortrags
[Techniques of Scientific Presentations]. H.O Gralky,
Freie Universität Berlin. Held in Berne,
Switzerland. |
| 11/1996 |
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Forum Gestaltung wissenschaftlicher Poster.
University of Berne |
| 06/14−06/15/1996 |
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PAGE meeting (Population
Approach Group in Europe). Sandwich, UK |
| 05/19−05/23/1997 |
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Short course and intermediate workshop in
population pharmacokinetic data analysis using the
NONMEM system. Stewart Beal and L.B. Sheiner, NONMEM
Project Group, UCSF. Held in, San Francisco, USA |
| 05/27−05/30/1998 |
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3rd International Symposium on Measurement and
Kinetics of in vivo Drug Effects. Leiden
University/Vrije Universiteit Amsterdam, The
Netherlands. Held in Noordwijkerhout, The
Netherlands |
| 04/11−04/16/1999 |
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Workshop on Advanced Pharmacokinetics and
Pharmacodynamics. L.B. Sheiner, UCSF, Malcolm
Rowland, University of Manchester. Held in San
Francisco |
| 06/25−06/26/1999 |
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Workshop on
Advanced Methods of Pharmacokinetic/Pharmacodynamic
System Analysis. Organized by David Z. D'Argenio,
University of Southern California, Biomedical
Simulation Resource. Held in Marina del Rey, CA,
USA |
| 06/15−06/16/2000 |
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PAGE meeting (Population
Approach Group in Europe). Salamanca, Spain |
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| Special software |
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S-Plus, R, NONMEM, Pharsight Trial Simulator (TS2), Berkeley Madonna |
| UNIX programming |
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FORTRAN, awk, perl, c-shell script, UNIX text
formatting (troff, tbl, eqn, bib), LaTeX, internet:
telnet, ftp |
| DOS/Windows |
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MS-Office programs, Reference Manager, Mathcad,
Internet browsers |
| NeXTstep |
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Lighthouse Diagram, SciPlot |
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| German |
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mother tongue |
| English, French |
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fluent oral and written skills |
| Spanish |
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basic communication skills |
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- Music, member of BernChor21
(choir in Berne) with regular concert
performances
- Hiking, cooking, baking bread, gardening,
Yoga
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- Nicolas Frey, PhD, Head of Modeling & Simluation, Hoffmann-La Roche, 4070 Basel
E-mail: nicolas.frey@roche.com
- Karin Jorga, PhD, Hoffmann-La Roche, 4070 Basel
E-mail: karin.jorga@roche.com
- Dominik E. Uehlinger, MD, Leitender Arzt,
Abt. für Nephrologie und Hypertonie,
Universität Bern, Inselspital,
Freiburgstrasse 10, 3010 Bern, Switzerland
Tel. +41 (0)31 632 31 44
E-mail: uehlinger@mph.unibe.ch
- Davide Verotta, PhD, Associate Professor,
Depts. Biopharmaceutical Sciences, Epidemiology
and Biostatistics, University of California, San
Francisco, CA 94143-0446, USA; Tel/fax: +415 476 1556
E-mail: davide@ariel1.ucsf.edu,
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| © Robert Stark, Bern,
2001-2009. Last Update: look at Home |
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